Thousands of Americans could be at high risk of colorectal cancer (CRC) but not realize it. Studies show that people with an immediate family member with CRC are two to four times more likely to develop the disease compared to those who don’t have such family history. But, according to…

A new study published in the Journal of the National Cancer Institute, has found that reducing disparities between Black and White people in colonoscopy follow-up completion rates and the quality of colonoscopy screenings would dramatically reduce colon cancer deaths. According to the study’s findings, efforts aimed at eliminating these disparities…

Quantitative methods paired with strict confounder control uncover more accurate microbiome colorectal cancer biomarkers, according to new research. Multiple microbial taxa have been put forward as potential cancer-associated biomarkers in the past, but this new study uncovers obscured contributions that may have resulted in incorrect associations.  This study shows that,…

Previous studies have demonstrated that long-term daily use of aspirin can help to delay the development and progression of colorectal cancer (CRC) but the mechanisms involved have not been fully understood. Now, researchers at the University of Padova have discovered aspirin may exert these protective effects by boosting certain aspects…

Colorectal and pancreatic cancers—the second and third leading causes of cancer death, respectively—often have mutations in the KRAS protein. Now, a new vaccine that targets KRAS has shown encouraging early results as a potential off-the-shelf treatment for patients with pancreatic cancer or colorectal cancer, according to a study co-led by…

New research has linked significant variations in the gut microbiome to pre-cancerous colonic lesions, according to findings presented at UEG Week 2023. The data points to ways of detecting and treating colon cancer. The large-scale prospective study, involving 8,208 participants, used data from the Dutch Microbiome Project with the Dutch…

Researchers from the Technical University of Munich in Germany have developed and validated a deep-learning algorithm that accurately differentiates colon cancer from acute diverticulitis on computed tomography (CT) images. They write in JAMA Network Open that the deep-learning model “may improve the care of patients with large-bowel wall thickening” when…

Administering chemotherapy to colon cancer patients before surgery reduces the risk of the cancer returning according to a clinical trial of patients in the UK, Denmark, Sweden. The FOxTROT trial, funded by Cancer Research UK, demonstrated a 28% reduce risk of colon cancer returning when chemotherapy was given before, instead…

Researchers from the University of Michigan Rogel Cancer Center have published new research in the journal Gastroenterology, showing that a low-protein diet disrupts a nutrient signaling pathways in cells that is a driver of colon cancer. The research focused on one of the most important cellular nutrient sensing molecule called…

Scientists at the Institute for Research in Biomedicine (IRB), in Barcelona have identified residual tumor cells responsible for colon cancer relapse and reveal the underlying mechanism behind their ability to metastasize. In the United States, colorectal cancer is the third leading cause of cancer-related deaths in men and women with…

Approximately one-in-25 people will develop colon cancer during their lifetime with nearly 2 million cases new cases are diagnosed worldwide each year. Chemotherapy is commonly used to treat colon cancer. While this treatment is initially effective in most cases, many patients relapse after treatment. New findings published in the journal…

Because of their high rates of recurrence even after successful first treatments such as surgery or radiotherapy, colorectal, pancreatic, esophageal, and stomach cancers remain some of the deadliest forms of the disease. While the success of immunotherapies has provided significant care improvements in some instances—non-small cell lung cancer being perhaps…

A new research study led by scientists at the Johns Hopkins Kimmel Cancer Center and WEHI demonstrates that circulating tumor DNA (ctDNA) can identify stage II colon cancer patients who can most benefit from chemotherapy following surgery. The findings are published in the New England Journal of Medicine in a paper titled…

Researchers at the University of Pittsburgh School of Medicine report in the journal Immunity, that a bacterium common in the mouse gut microbiome may aid the immune system in fighting cancer cells in the colon. These new findings could eventually inform the development of new therapeutics based on the small…

Research from the University of Washington School of Medicine suggests that presence of the bacteria Bacteroides fragilis in precancerous gut polyps could correlate with an increased risk for developing colon cancer. The team found that individuals with these bacteria present in their polyps had increased inflammation and seemed to induce…