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Published on April 16, 2024
Researchers at the McMaster University, in a new meta-analysis, have found that donepezil, a medication commonly prescribed for dementia does not increase the risk of death and certain heart rhythm problems, contrary to past warnings. The research, published in the Journal of the American Geriatrics Society, noted that past warnings…
Published on April 1, 2024
Smartphones could help detect dementia early on by reliably and remotely assessing cognitive function, research suggests. A mobile app was able to identify early frontotemporal lobar degeneration, a neurodegenerative pathology that involves changes in personality, cognition, movement, speech, and language. The app identified frontotemporal dementia (FTD) before symptoms appeared in…
Published on March 28, 2024
Brain blood vessel damage that increases the risk of stroke and dementia is common in people with a range of heart conditions, regardless of whether they have experienced a stroke, a new study shows. The team’s findings could help in choosing appropriate treatments for these patients, said lead author Zien…
Published on February 13, 2024
Research led by Fudan University in Shanghai, China shows high levels of specific blood proteins can predict the onset of dementia 10 years or more in the future. Of the many proteins tested, Glial fibrillary acidic protein (GFAP), neurofilament light chain protein (NEFL), growth/differentiation factor 15 (GDF15), and latent-transforming growth…
Published on February 9, 2024
Mutated C9orf72 may cause many cases of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) through the overproduction of Interleukin-17A (IL-17A), a potent inflammatory molecule, according to new work from researchers at the Harvard Stem Cell Institute and collaborators. Treatments that block IL-17A have already been approved by the U.S.…
Published on January 18, 2024
A large-scale data analysis suggests about a quarter of dementia cases are linked to race or controllable risk factors, such as high blood pressure, diabetes, physical inactivity, and too little or too much sleep. Adding gene variant APOE ε4 status to the analysis boosted the number of explainable cases to…
Published on December 28, 2023
Researchers from the University of Exeter in the U.K. and Maastricht University in the Netherlands have identified 15 risk factors associated with young-onset dementia, challenging the prevailing belief that genetics are the sole culprit, paving the way for innovative prevention strategies. Young-onset dementia, a term describing the development of dementia…
Published on December 14, 2023
Reporting in Neurology, researchers from Monash University in Melbourne, Australia, reveal a compelling link between very irregular sleep patterns and an elevated risk of dementia. “Sleep health recommendations often focus on getting the recommended amount of sleep, which is seven to nine hours a night, but there is less emphasis on…
Published on November 29, 2023
Results from a UK Biobank study show people who develop coronary heart disease (CHD) have increased dementia risk in later life particularly those who develop heart disease before the age of 45 years. Led by the Chinese Academy of Medical Sciences and Peking Union Medical College in Beijing, China, the…
Published on November 27, 2023
Cognitive decline can be slowed with personalized therapy, according to results of The Systematic Multi-Domain Alzheimer Risk Reduction Trial (SMARRT), published today in JAMA Internal Medicine. This was a randomized clinical trial that included a two-year, personalized, dementia risk-reduction intervention program. The lead author was Kristine Yaffe, MD, of the…
Published on October 31, 2023
Results from a study led by Radboud University Medical Center in the Netherlands shows frequent changes in blood pressure only increase dementia risk in people who are 90 years or older. However, the findings showed that individuals between the age of 60 and 89 with high blood pressure variability did…
Published on October 27, 2023
New research led by the University College London (UCL) reveals a troubling projection: up to 1.7 million people could be living with dementia in England and Wales by 2040. This estimate, over 40 percent higher than previously forecast, is raising concerns among healthcare experts and policymakers, as it points to…
Published on September 6, 2023
Research led by the University of Rochester shows antipsychotics are frequently given to patients with Alzheimer’s disease and related dementias and that use of such drugs is linked to reduced physical improvement in these individuals. “Antipsychotic use in persons with dementia is a serious patient safety issue, and it should…
Published on August 28, 2023
The neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) which usually manifest later in life may have their roots before a person is born, during embryonic brain development. These are the findings a study published last week in the journal Cell Reports by researchers at the Keck School…
Published on August 23, 2023
A large study finds that catheter ablation is linked to almost 50% lower risk of dementia and lower deaths in all types of patients with atrial fibrillation. The research was reported in the Journal of the American Geriatrics Society. It included more than 40,000 individuals with atrial fibrillation (AF) who…