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Published on April 17, 2024
By Pranali Pachika, Srijan Valasapalli, Phuong Ngo, and Goetz Kloecker “Artificial intelligence” (AI) is the study and production of computing methods and models that replicate human intelligence in perception, speech recognition, decision making, and language processing.1 AI is utilized in oncology to improve cancer diagnosis, treatment planning, and patient outcomes by analyzing massive volumes of data from…
Published on April 17, 2024
A recent discovery by researchers at the University of Arizona Medical School – Phoenix has shown that nanoparticle delivery of frizzled-4 (FZD4) to lung endothelial cells slows lung cancer progression and metastases. “We have identified the novel protein FOXF1 that stabilizes blood vessels inside the lung tumors, decreases intertumoral hypoxia…
Published on April 12, 2024
Reporting in Science Advances, scientists at the Fred Hutchinson Cancer Center in Seattle have presented a blood-based test, known as liquid biopsy, capable of accurately distinguishing between types and subtypes of small cell lung cancer (SCLC), offering hope for precise diagnosis and personalized treatment plans for patients. SCLC, an aggressive…
Published on April 3, 2024
A team of researchers at Zhejiang University has developed a novel way to use cryo-shocked tumor cells to combat lung cancer. The researchers used a delivery vehicle for CRISPR-Cas9 that is more effective than lipid nanoparticles (LNPs) in treating lung cancer. In a mouse model of non-small cell lung cancer…
Published on March 26, 2024
A nearly 10-year-old Medicare policy that was enacted to encourage the use of lung cancer screening in patients with comorbidities needs major changes to improve patient-provider shared decision making and eliminate patient selection bias for these procedures. This, according to a study published today in the Annals of Family Medicine,…
Published on February 28, 2024
Heterozygosity in human leukocyte antigen (HLA) reduces risk of developing lung cancer, according to a new study led by researchers at the Icahn School of Medicine at Mount Sinai. Surprisingly, this effect was particularly pronounced among smokers. The researchers suggest that by considering immune genetics alongside hereditary and environmental factors,…
Published on February 21, 2024
Scientists have discovered a way to use inhalable exosomes to deliver interleukin-12 (IL-12) mRNA to the lungs for cancer therapy. The technology provides a means of achieving sufficiently concentrated IL-12 levels in the lungs and bypassing some of the off-target side effects of IL-12 therapy delivered systemically through other delivery…
Published on February 14, 2024
Scientists have discovered the molecular events driving the conversion of EGFR-driven lung adenocarcinoma to an aggressive neuroendocrine cancer indistinguishable from small cell lung cancer (SCLC). For the first time, the team revealed that the Myc oncogene alone is capable of this type of histological transformation in SCLC. The discovery raises…
Published on January 16, 2024
Researchers from the UCLA Health Jonsson Comprehensive Cancer Center have published new research in the journal JAMA Oncology demonstrating that chemotherapy plus high doses of radiation are a safe and effective treatment for people with locally advanced non-small cell lung cancer (NSCLC) that is not suitable for surgery. The Jonsson…
Published on January 10, 2024
To make lung cancer screening more readily available in low-resource settings, researchers at MIT have developed a urine-based point-of-care test using inhaled aerosolized nanosensors that are delivered to patients by an inhaler or nebulizer. If the sensors encounter cancer-linked proteins in the lungs, they produce a signal that accumulates in…
Published on January 3, 2024
Current clinical guidelines call for annual lung cancer screening of patients 50 years and older with a history of smoking using low-dose computed tomography. Previous results from the National Lung Screening Trial (NLST) have shown that this screening increases early detection and reduces mortality. However, a new study published in…
Published on December 20, 2023
New research shows that the adoption of a Lung Nodule Program (LNP) can significantly enhance the detection of early lung cancer among individuals not meeting the age eligibility criteria for traditional lung cancer screening. LNPs are often set up as a way to follow up with patients when lung nodules…
Published on November 30, 2023
In a clinical validation study, Veracyte’s Percepta Nasal Swab Test determined lung cancer risk with high accuracy, among people who currently smoke or have previously smoked and have lung nodules. The findings suggest the novel, non-invasive, genomic test can help physicians better decide next steps for these patients. Low-risk patients…
Published on November 29, 2023
To identify the 10% to 20% of lung cancers in people who have never smoked, researchers have developed an AI-deep learning too that flags non-smokers at high-risk for lung cancer from a single chest X-ray. Known as the Chest-X-ray (CXR) Lung-Risk tool, researchers from Massachusetts General Hospital presented data at…
Published on November 15, 2023
A survey of people in the U.S. at high risk for lung cancer has shown that most would be willing to accept risks associated with lung cancer interception therapy—such as serious infection—if it meant their lung cancer risk was reduced. There are currently no approved treatments that actively interrupt the…