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The seed-sized brain-like organoids are reminiscent of one wrinkle in the human brain 15 to 19 weeks post-conception.

In this Learning Lab, sponsored pHcbi, we discussed the development of respiratory airway and alveolar organoids derived from human iPSCs and how these are used in modeling respiratory diseases such as cystic fibrosis.

Custom-made kidney organoids have pointed to which cells, and pathways, cause tumors in patients with tuberous sclerosis complex (TSC).

University of California, San Diego (UCSD), School of Medicine scientists used human brain organoids to reveal how a genetic mutation associated with a profound form of autism disrupts neural development. The scientists used gene therapy tools to recover the gene’s function.

The fallopian tube-based organoids may help predict which individuals with BRCA-1 mutations will develop ovarian cancer years or even decades in advance, and could be used to develop personalized therapies.

Immunotherapies tested on the organoids can potentially support treatment decisions and can achieve personalized results by identifying beneficial treatments while sparing patients from the harmful side effects of drugs from which they will obtain no benefit. 

SARS-CoV-2 affects many parts of the body. Although the primary manifestations of COVID-19 involve the respiratory system, gastrointestinal effects may play a critical role in both disease severity and transmission.

Generated from human induced pluripotent stem cell (iPSC), researchers created lung organoids and cerebral organoids, to study the reactions of neural progenitor cells (NPCs), neurons, and astrocytes to infection from SARS-CoV-2.

Besides shedding new light on microencephaly, CRISPR-LICHT demonstrates a CRISPR screening approach that could be applied to other organoids to simplify the rapid testing of candidate genes for a range of human diseases.

Researchers from the group of Hans Clevers at the Hubrecht Institute believe their new method, CRISPR-HOT, can be applied to many types of human organoids, to visualize any gene or cell type, and to study many developmental and disease related questions.