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Neutrophils Major Culprits in Pancreatic Cancer Treatment Resistance
A new study has demonstrated for the first time the method by which immature neutrophils, a type of white blood cell, are controlled by pancreatic cancers to drive both immunosuppression and treatment resistance.
Immune Cell Specific to Women with Pancreatic Cancer Suggests Possible Sex-Specific Treatments
Recent research has identified in women with pancreatic cancer the presence of a population of immune cells that highly expresses a protein called FPR2, and which obstructs the body’s immune response.
Pancreatic Cancer Tumor Microenvironment Reveals New Targets
A new study that analyzed the tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) revealed new insights into why immunotherapy does not work well in this cancer type.
Four-Drug Chemotherapy Regimen Shows Promise for Advanced Pancreatic Cancer
Treating metastatic pancreatic ductal adenocarcinoma (mPDAC) with a four-drug chemotherapy regimen prolongs survival by around 2 months compared with a commonly used two-drug regimen.
Tumor Immune Microenvironment in Pancreatic Cancer Reprogrammed by Combo Therapy
A combination of immunotherapies targeting both T cells and myeloid suppressor cells was able to reprogram the tumor immune microenvironment and improved anti-tumor response in pancreatic cancer models.
KRAS Inhibitor Boosts T Cell Production, Shrinks Pancreatic Cancer Tumors
The drug inhibits the activity of the most common KRAS mutation in pancreatic cancer and simultaneously boosts T cell-mediated immunity.
Study Shows Success of New Anti-KRAS Drug for Pancreatic Cancer
Researchers show how new anti-KRAS drug for pancreatic cancer shrinks tumors and interacts with the immune system.
MRI-Guided Adaptive Radiation Pancreatic Cancer Therapy Show Promise
Delivery of ablative doses of radiation to patients with pancreatic cancer has shown promising safety and patient outcomes data for locally advanced and borderline resectable pancreatic cancer treatment.
New Combination Pancreatic Cancer Therapy Shows Promise in Mouse Models
The novel treatment implants radioactive iodine-131 directly into the tumor within a gel-like depot that protects healthy tissue and is absorbed by the body after the radiation fades away.
Pancreatic Cancer Development Step Reversed by Two Compounds
Researchers have identified two small molecules that have shown the ability to inhibit precancerous cell progression. Further, the molecules also reversed a process called acinar ductal metaplasia (ADM) which precedes pancreatic cancer.