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Neutrophil white blood cell, illustration

Neutrophils Major Culprits in Pancreatic Cancer Treatment Resistance

A new study has demonstrated for the first time the method by which immature neutrophils, a type of white blood cell, are controlled by pancreatic cancers to drive both immunosuppression and treatment resistance.
Pancreatic Cancer Concept

Immune Cell Specific to Women with Pancreatic Cancer Suggests Possible Sex-Specific Treatments

Recent research has identified in women with pancreatic cancer the presence of a population of immune cells that highly expresses a protein called FPR2, and which obstructs the body’s immune response.
Pancreatic Cancer Concept

Pancreatic Cancer Tumor Microenvironment Reveals New Targets

A new study that analyzed the tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) revealed new insights into why immunotherapy does not work well in this cancer type.
Hospitalized cancer patient undergoing chemotherapy.

Four-Drug Chemotherapy Regimen Shows Promise for Advanced Pancreatic Cancer

Treating metastatic pancreatic ductal adenocarcinoma (mPDAC) with a four-drug chemotherapy regimen prolongs survival by around 2 months compared with a commonly used two-drug regimen.
Pancreatic cancer, malignant tumor of pancreas with KRAS mutation

Tumor Immune Microenvironment in Pancreatic Cancer Reprogrammed by Combo Therapy

A combination of immunotherapies targeting both T cells and myeloid suppressor cells was able to reprogram the tumor immune microenvironment and improved anti-tumor response in pancreatic cancer models.
Pancreatic cancer, illustration

KRAS Inhibitor Boosts T Cell Production, Shrinks Pancreatic Cancer Tumors

The drug inhibits the activity of the most common KRAS mutation in pancreatic cancer and simultaneously boosts T cell-mediated immunity.
Pancreatic cancer, malignant tumor of pancreas with KRAS mutation

Study Shows Success of New Anti-KRAS Drug for Pancreatic Cancer

Researchers show how new anti-KRAS drug for pancreatic cancer shrinks tumors and interacts with the immune system.
Doctor team

MRI-Guided Adaptive Radiation Pancreatic Cancer Therapy Show Promise

Delivery of ablative doses of radiation to patients with pancreatic cancer has shown promising safety and patient outcomes data for locally advanced and borderline resectable pancreatic cancer treatment.
Micrograph of pancreatic neuroendocrine tumor, clear cell variant

New Combination Pancreatic Cancer Therapy Shows Promise in Mouse Models

The novel treatment implants radioactive iodine-131 directly into the tumor within a gel-like depot that protects healthy tissue and is absorbed by the body after the radiation fades away.
Pancreatic Cancer Concept

Pancreatic Cancer Development Step Reversed by Two Compounds

Researchers have identified two small molecules that have shown the ability to inhibit precancerous cell progression. Further, the molecules also reversed a process called acinar ductal metaplasia (ADM) which precedes pancreatic cancer.


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