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Published on May 19, 2022
Large-scale changes in functional connectivity in the brain occur in patients with treatment-resistant depression administered targeted magnetic stimulation, which researchers believe could help predict treatment response. Repetitive transcranial magnetic stimulation (rTMS) is used to treat patients with depression who do not respond to antidepressants, which is nearly 40% patients with…
Published on May 16, 2022
A new mouse model may help explain how depression and prolonged and severe stress increase heart disease risk and affect response to lipid-lowering drugs. The researchers say this is the first study to use a mouse model of chronic stress and depression to investigate whether and how chronic stress may…
Published on April 7, 2022
Hereditary factors are partly responsible for childhood anxiety and depression that persists into adulthood, according to University of Queensland researchers. The largest study of its kind in the world looked at genetics from more than 65,000 children, aged between three and 18 years. It’s the first time researchers have conducted…
Published on February 18, 2022
Epidemiological data have long linked depression with Alzheimer’s disease (AD), a neurodegenerative disease characterized by progressive dementia that affects nearly six million Americans. Now, a new study identifies common genetic factors in both depression and AD. Importantly, the researchers found that depression played a causal role in AD development, and…
Published on January 10, 2022
Results from a study in mice, led by researchers at Université Laval in Canada, suggest that sex differences occur in how the brain responds to stress, which the team has also found evidence for in in humans with depressive symptoms. More research is needed to confirm the findings, but the…
Published on January 6, 2022
A biomarker in human platelets that tracks the extent of depression has been found by researchers at the University of Chicago. This proof-of-concept study builds off of previous work that has shown, in humans and animal models, that depression is consistent with decreased adenylyl cyclase — a small molecule inside…
Published on October 5, 2021
For patients with long-term, treatment-resistant depression, a new precision therapeutic approach developed by researchers at at the University of California San Francisco (UCSF) could be transformative in alleviating their symptoms. Findings of their work in deep brain stimulation were published recently in the journal Nature Medicine. “This study points the…
Published on April 12, 2021
A research study led by Emory University School of Medicine has identified 19 genes and 25 brain proteins that could cause depression, which the team hopes will help in the search for new treatments. The researchers used a new approach combining genome wide association study (GWAS) data with human brain…
Published on April 8, 2021
Current methods for diagnosing and treating depression remain largely trial and error with no objective measures or blood tests available. But a team led by Alexander Niculescu, M.D., Ph.D., professor of psychiatry at Indiana University, is hoping to bring personalized medicine approach to the condition and other mood disorders. They…
Published on April 20, 2020
Emotional, social, and psychiatric problems in children and adolescents have been linked to higher levels of genetic vulnerability for adult depression, according to University of Queensland scientists. They made the finding “Genetic Associations Between Childhood Psychopathology and Adult Depression and Associated Traits in 42 998 Individuals: A Meta-Analysis”, which appears in JAMA…
Published on October 30, 2019
Researchers in the United States and Switzerland have identified neural subcircuits and genetic biomarkers in mice that are linked with a common symptom of depression. The studies, headed by a team at the University of California (UC), Berkeley, identified the gene targets for treating lack of motivation in a mouse…
Published on October 29, 2019
While there are a number of genes that have been linked to depression, it is broadly accepted that the mental health condition arises from a complex interaction of a person’s molecular make up. But now, researchers have constructed a polygenic risk score (PRS) for major depressive disorder, or MDD-PRS, from…
Published on August 2, 2019
The nation’s largest private health insurer, UnitedHealthcare, announced August 1 that it will cover testing that will allow physicians to match their patients to anti-depressants most likely to work for them based on their genetic profiles. The new coverage policy, which also includes multi-gene panel testing for antipsychotic medications, goes…
Published on July 3, 2019
Researchers suggest that individual variation in genes alters our ability to regulate emotions, providing new insights that could help in the development of personalized therapies to tackle anxiety and depression. Some individuals are at greater risk of developing anxiety and depression than others and this depends in part upon the…
Published on February 6, 2019
The results of a genome-wide meta-analysis of genetic data from more than two million individuals has linked 102 genetic variants and 269 genes with depression, and found associations between the psychiatric disorder and a number of behavioral traits. The researchers, headed by a team at the University of Edinburgh, say…