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Micrograph of Renal Cell Carcinoma (RCC)

Microscopy Findings Plus PBRM1 Status Predict Kidney Cancer Immunotherapy Response

H&E-stained tumor tissue on microscopy slides can predict which patients with metastatic clear cell renal cell carcinoma (mccRCC) are most likely to respond to immunotherapy, with the prediction further refined by adding PBRM1 mutation status, research suggests.
Lymphocyte, closeup view of T-cell or B-cell

Non-Invasive Immunotherapy Approach Could Improve the Future of Cancer Treatment

Scientists have developed a new technology for immunotherapy that isolates T cells from the blood instead of tumor tissue.
Lymphocytes attacking a cancer cell, illustration

Study Shows Mechanisms of How Probiotics Make Melanoma Immunotherapy More Effective

University of Pittsburgh researchers have detailed how probiotic bacteria travel from the gut to cancer tumors and then stimulate immune cells to make immunotherapy more effective.
NK Cell (Natural Killer Cell) Attacking a Cancer Cell

Cancer Immunotherapy Expansion Using a New Predictive Biomarker

In this Inside Precision Medicine webinar, our distinguished guest speaker, Dr. Scott Tomlins, described the development, validation, and clinical utility of a new pan-tumor predictive biomarker for immunotherapy benefit: Immunotherapy Response Score (IRS).
T-Cells Attacking Cancer Cell

Blocking T-Cell Migration with Immunotherapy Slows Melanoma Growth

Using a chemical blocker stops CD8+ T cells from migrating out of skin cancer cells. Together with immunotherapy, this new approach could boost the efficacy of immunotherapy.
3d illustration of a cross-section of a diseased skin with melanoma that enters the bloodstream and lymphatic tract

Immunotherapy Response Affected by CD5+ Cells

CD5+ cells could be an important marker for response to immunotherapy for melanoma and other cancers, according to new research from the Washington University School of Medicine. 
Lung cancer, illustration

New Insights to Poor Lung Cancer Response to Immunotherapy

Bacteria naturally found in the lungs help create an environment that suppresses T-cell activation in the lymph nodes near the lungs—a finding that could explain why immunotherapy for lung cancer often fails.
Tumor microenvironment

Persistent Mutations in Tumors May Predict Response to Immunotherapy

New evidence from researchers at the Johns Hopkins Kimmel Cancer Center has found that a subset of mutations within the TMB—defined at “persistent mutations"—are less likely than others to be edited out, making them always visible to the immune system which results in them being more likely to respond to immunotherapies.
3d illustration of a cross-section of a diseased skin with melanoma that enters the bloodstream and lymphatic tract

Melanoma Immunotherapy Boosted by Sugar Found in Seaweed

L-fucose, a nontoxic dietary plant sugar that is enriched in red and brown seaweeds, can increase TILs, promote antitumor immunity, and improve the efficacy of immunotherapy.
Colorectal polyps, illustration

Pre-Surgery Immunotherapy for Colorectal Cancer Proves Highly Effective

Using immune checkpoint inhibitors prior to surgery of patients with localized mismatch repair-deficient or microsatellite instability-high (dMMR/MSI-H) colorectal cancer (CRC) is an effective approach to treating the disease


Inside Precision Medicine