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Published on June 14, 2023
Researchers have discovered a previously unknown role of minor introns, which constitute less than 0.5% of all introns, in gene expression and role in prostate cancer progression and resistance to treatment. The team also demonstrated that use of a siRNA inhibited the minor spliceosome, resulted in prostate cancer cell death,…
Published on June 12, 2023
Novartis today announced it will pay $3.2B to acquire Chinook Therapeutics, a Seattle-based biopharmaceutical company with two late-stage medicines in development for rare, severe, chronic kidney diseases, including Immunoglobulin A Nephropathy (IgAN). Such drugs are the vanguard of targeted therapy for IgAN. As Selvaskandan et al. wrote in one recent…
Published on May 31, 2023
The broad application of precision medicine has, until now, been largely hampered by the methods available to query the full complexity of humans and human disease. For instance, while immortalized cell lines have long been a workhorse of research in human biology, they are not able to reproduce the heterogeneity…
Published on May 24, 2023
During Axiom Space’s first Private Astronaut Mission, the scientists discovered that in low Earth orbit, cancer stem cells appeared to regenerate more easily and become more resistant to standard therapies. The Ax-2 low Earth orbit mission will now determine if two inhibitory drugs can reverse the regeneration in a breast…
Published on May 24, 2023
Researchers led by a team from the University of Helsinki in Finland have identified three different evolutionary states in tumors from patients with ovarian high-grade serous carcinoma (HGSC) that are characterized by distinct signaling pathways and associated with treatment response. HGSC is the most common epithelial ovarian cancer subtype and…
Published on April 11, 2023
Research led by the University of Basel shows that the antioxidant and dietary supplement N-acetylcysteine could help combat a type of drug resistance in breast cancer. The PI3K signaling pathway is commonly overactive in breast cancer patients due to genetic mutations. The approval of the PI3K inhibitor alpelisib by the…
Published on March 21, 2023
Research led by the University of California, Los Angeles, shows base editing could be used to treat a rare immune disorder known as CD3 delta severe combined immunodeficiency (SCID). Writing in the journal Cell, the authors describe using base editing, a new and more precise version of gene editing than…
Published on March 15, 2023
The gene CIART is a major factor in the establishment of a COVID-19 infection, according to a new study from researchers at Weill Cornell Medicine and New York University (NYU) Grossman School of Medicine. In the study, which appears this week in Nature Cell Biology, the researchers used multiple organoids to…
Published on February 8, 2023
A new algorithm leveraging artificial intelligence machine learning appears to reveal the key drivers of two types of glioblastoma multiforme (GBM) that together represent half of all GBMs. Even though GBMs are a variable group of subtypes, the treatment for all remains the same. To better provide more targeted treatments,…
Published on January 11, 2023
New findings from a team at NYU Langone Health’s Perlmutter Cancer Center published recently in Cancer Cell, has identified a gene that drive the development of lung squamous cell carninoma (LUSC)—a major subtype of lung cancer with limited treatment options. “LUSC represents a major subtype of lung cancer with limited…
Published on December 20, 2022
It seems like a slam dunk. Why not repurpose already approved or well-studied drug candidates for conditions where treatments are desperately needed? Wouldn’t that be an easy way to speed up drug development? There are multiple examples where that has been very successful (see Stunning Success Stories). But there are…
Published on August 11, 2022
Disrupting the circadian clock of cells, such as through shift work, could play an important role in the alarming rise of colorectal cancer in younger people, research suggests. The study in mouse and human tissue found that genetic disruption of this internal, biological pacemaker drove progression of the cancer through…
Published on July 19, 2022
ViroTreat, a novel integrative, regulatory network-based model for rapid identification of antiviral drugs has been validated by DarwinHealth scientists and their international colleagues. The team showed that 15 of the 18 drugs (83%) predicted to be effective induced significant reduction of SARS-CoV-2 replication, without affecting cell viability. In contrast, none of…
Published on July 6, 2022
The protein GREM1 Is a key regulator of cellular heterogeneity in mouse and human pancreatic cancer, according to recent work from The Institute of Cancer Research (ICR), London. According to this work manipulating GREM1 levels can fuel or reverse the ability of pancreatic cancer cells to change into a more…
Published on July 6, 2022
Approximately one-in-25 people will develop colon cancer during their lifetime with nearly 2 million cases new cases are diagnosed worldwide each year. Chemotherapy is commonly used to treat colon cancer. While this treatment is initially effective in most cases, many patients relapse after treatment. New findings published in the journal…