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Generated from human induced pluripotent stem cell (iPSC), researchers created lung organoids and cerebral organoids, to study the reactions of neural progenitor cells (NPCs), neurons, and astrocytes to infection from SARS-CoV-2.

Besides shedding new light on microencephaly, CRISPR-LICHT demonstrates a CRISPR screening approach that could be applied to other organoids to simplify the rapid testing of candidate genes for a range of human diseases.

Researchers from the group of Hans Clevers at the Hubrecht Institute believe their new method, CRISPR-HOT, can be applied to many types of human organoids, to visualize any gene or cell type, and to study many developmental and disease related questions.

The researchers were able to combine melanoma cells and white blood cells from the patients’ peripheral blood and lymph nodes and create patient-specific, immune-active tumor organoids to test their response to immunotherapy treatment.

How do researchers, looking to create more realistic disease models—along with more targeted therapies—overcome the shortcomings of these models? Increasingly, it is via the use of human organoids. Advances over the past dozen or so years in the methods for growing these three-dimensional models has resulted in a significant uptick in their use in precision medicine research.

The Ax-2 low Earth orbit mission will determine if two inhibitory drugs can reverse the regeneration in a breast cancer organoid model.

Researchers have identified three different evolutionary states in tumors from patients with ovarian high-grade serous carcinoma (HGSC) that are characterized by distinct signaling pathways and associated with treatment response.

The antioxidant N-acetylcysteine could help overcome resistance to alpelisib in PI3Kalpha mutated breast cancer patients.

Base editing, a precise form of gene editing, has been used to correct a genetic mutation causing a rare immunodeficiency disease in the lab.

The gene CIART is a major factor in the establishment of a COVID-19 infection, according to a new study.