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Lung, Cerebral Organoids Reveal Responses to SARS-CoV-2 Infection
Generated from human induced pluripotent stem cell (iPSC), researchers created lung organoids and cerebral organoids, to study the reactions of neural progenitor cells (NPCs), neurons, and astrocytes to infection from SARS-CoV-2.
25 New Microcephaly Genes Identified via CRISPR Screen for Human Organoids
Besides shedding new light on microencephaly, CRISPR-LICHT demonstrates a CRISPR screening approach that could be applied to other organoids to simplify the rapid testing of candidate genes for a range of human diseases.
New CRISPR Tool to Light Up Organoid Genes
Researchers from the group of Hans Clevers at the Hubrecht Institute believe their new method, CRISPR-HOT, can be applied to many types of human organoids, to visualize any gene or cell type, and to study many developmental and disease related questions.
Immune-Enhanced Organoids Could Provide Immunotherapy Screening Platform
The researchers were able to combine melanoma cells and white blood cells from the patients’ peripheral blood and lymph nodes and create patient-specific, immune-active tumor organoids to test their response to immunotherapy treatment.
Modeling Disease in 3D
How do researchers, looking to create more realistic disease models—along with more targeted therapies—overcome the shortcomings of these models? Increasingly, it is via the use of human organoids. Advances over the past dozen or so years in the methods for growing these three-dimensional models has resulted in a significant uptick in their use in precision medicine research.
Cancer Research Moves to Low Earth Orbit
The Ax-2 low Earth orbit mission will determine if two inhibitory drugs can reverse the regeneration in a breast cancer organoid model.
Distinct Ovarian Cancer Evolution States May Offer Personalized Treatment Options
Researchers have identified three different evolutionary states in tumors from patients with ovarian high-grade serous carcinoma (HGSC) that are characterized by distinct signaling pathways and associated with treatment response.
Antioxidant Could Help Combat Drug Resistance in Breast Cancer
The antioxidant N-acetylcysteine could help overcome resistance to alpelisib in PI3Kalpha mutated breast cancer patients.
Base Editing Shows Promise for Treating Rare Immune Disorder
Base editing, a precise form of gene editing, has been used to correct a genetic mutation causing a rare immunodeficiency disease in the lab.
CIART Gene Found to Play Key Role in SARS-CoV-2 Infection
The gene CIART is a major factor in the establishment of a COVID-19 infection, according to a new study.