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Published on July 12, 2023
A team led by the Wellcome Sanger Institute and the National Heart and Lung Institute at Imperial College London have produced an in-depth map of the human heart cells and tissue, as well as giving insight into how they communicate with each other. As reported in Nature, the research team…
Published on July 6, 2023
New findings may explain why some children with leukemia have a longer remission than others after having CAR T-cell therapy. Researchers at University College London (UCL), Great Ormond Street Hospital, and the Wellcome Sanger Institute identified a unique signature in chimeric antigen receptor (CAR) T-cells that are long lasting—a key…
Published on July 5, 2023
Researchers at the Massachusetts Institute of Technology (MIT) say they have used a vaccine that boosts CAR T therapy and it may be a method that can help this form of immunotherapy effectively treat solid tumors. The MIT researchers have found a way to overcome one of the obstacles to…
Published on June 23, 2023
Chimeric antigen receptor T-cell therapy, commonly referred to as CAR-T, has been an approved therapy for various forms of blood cancer. Now, evidence from a small clinical trial has indicated that a CAR-T adaptation could treat myasthenia gravis, a rare autoimmune disease of the nervous system. In the trial, the…
Published on June 14, 2023
Researchers have used heart and lung stem cells infected with SARS-CoV-2, the virus that causes COVID-19, to better understand how the disease impacts different organs. Responses varied significantly depending on the cell type, allowing the team to identify effective antiviral drugs to treat infection in these organs specifically, thus paving…
Published on June 8, 2023
Researchers at the Perelman School of Medicine at the University of Pennsylvania have received a seven-year, $6 million grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health (NIH) to discover how the development and maintenance of heart cells is influenced by DNA. The hope…
Published on June 5, 2023
Chimeric antigen receptor T cell therapy, commonly referred to as CAR T therapy, is an intervention that uses a patient’s own cells to fight their cancer. The therapy first received US Food and Drug Administration (FDA) approval in 2017. For some patients, this meant long term remission and even cures…
Published on May 31, 2023
Scientists at Baylor College of Medicine have demonstrated that in animal models of breast cancer and prostate cancer, eliminating the gene SRC-3 specifically in a type of immune cell called regulatory T cells (Tregs) triggered a lifelong anticancer response that eradicated the tumor without the typical side effects observed with…
Published on May 24, 2023
Scientists at the German Cancer Research Center (DKFZ) sought to determine the role of gastrointestinal B cells in the development of nonalcoholic steatohepatitis (NASH), fibrosis, and NASH-induced HCC. They discovered B cells promote liver cancer with a dual strategy. Their findings are published in the Journal of Hepatology. “Worldwide, fatty…
Published on May 22, 2023
A team of researchers in the Netherlands reports today in the journal Microbiology Spectrum that the compound honokiol, that is found in the bark of multiple species of magnolia trees, inhibits replication of the SARS-CoV-2 virus in several types of cells. Their research showed that in these cells, honokiol caused…
Published on May 17, 2023
Research led by Baylor College of Medicine and Texas Children’s Cancer Center shows hopeful results in a first-in-human phase I clinical trial using genetically engineered natural killer T cell (NKT) immunotherapy to treat neuroblastoma. Neuroblastoma is the most common cancer in infants, arising from immature nerve cells and predominantly affecting…
Published on April 17, 2023
An “off-the-shelf” allogeneic CAR T-cell therapy, developed by Allogene Therapeutics and tested by the University of Texas MD Anderson Cancer Center, showed promising results in a Phase I trial to treat patients with metastatic clear cell renal cell carcinoma. The advent of immunotherapy revolutionized cancer treatment. Combined gene and cell…
Published on March 30, 2023
A newly created nanoparticle that carries a messenger RNA (mRNA) payload that can be administered to the lungs may offer a method to provide an inhalable treatment for cystic fibrosis and other lung diseases. Designed by engineers at MIT and the University of Massachusetts Medical School and applied in a…
Published on March 22, 2023
Gut microorganisms influence non-Hodgkin lymphoma patient outcomes to chimeric antigen receptor T-cell (CAR T) therapy, according to a recent multinational research collaboration. A key finding of this study was that patients who had higher levels of the bacterium Bifidobacterium longum had an improved overall survival rate after CAR T. The team…
Published on March 16, 2023
Researchers at the Perelman School of Medicine at the University of Pennsylvania have developed a new and improved CAR T cell therapy approach for solid tumors by simultaneously knocking out two inflammatory regulators and boosting T cell expansion. CAR T cells are immune cells taken from an individual patient and genetically…