Encouraging results from this trial were presented at the American Association for Cancer Research (AACR) Annual Meeting 2024 by Timothy Yap, MBBS, PhD, of the University of Texas MD Anderson Cancer Center. Specifically, Yap reported that saruparib demonstrated early efficacy and a favorable safety profile in patients with HRR-deficient breast…

Aiming to increase access to specialized genetic testing, the Inter-Organization Cancer Genetics Clinical Evidence Coalition (INTERACT) was launched today by Ambry Genetics and collaborators. The group’s mission is to increase access to genetic testing for people with, or at risk of, hereditary cancers. The coalition also seeks impact on medical…

More people could benefit from personalized cancer immunotherapy using a newly developed discovery platform that can identify novel biomarkers and targets for treatment. The “identify-prioritize-validate” (IPV) pipeline offers a more accessible and reliable way to identify neoantigen proteins that are produced by genetic mutations in a tumor and the immune…

A new process tested at University of Kentucky (UK) expands access to germline genetic testing for cancer patients by reporting research-grade germline sequencing to the clinical oncology team. Over a third of pathogenic/likely pathogenic germline variants (PGVs) identified using a universal testing strategy would have been missed by a guideline-based…

European cancer mortality predictions for 2024 highlight a concerning increase in colorectal cancer deaths among people aged 29–45 years that the researchers suggest is linked to increasing rates of overweight and obesity. For the 14th consecutive year, Carlo La Vecchia, professor of Medical Statistics and Epidemiology at the University of Milan…

In the largest study of its kind, scientists have shown how combining health data with whole genome sequence (WGS) data could help doctors provide cancer patients better tailored care. The study analyzed over 30 types of solid tumors collected from more than 13,000 cancer patient data from Genomics England’s 100,000…

To identify the 10% to 20% of lung cancers in people who have never smoked, researchers have developed an AI-deep learning too that flags non-smokers at high-risk for lung cancer from a single chest X-ray. Known as the Chest-X-ray (CXR) Lung-Risk tool, researchers from Massachusetts General Hospital presented data at…

The Institute for Systems Biology (ISB) and NED Biosystems (NED) will collaborate on an intriguing clinical trial that aims to use a cocktail of several marketed medications at low doses to reverse cancer’s onset or regrowth. Leroy Hood, MD, PhD, co-founder of ISB and Rebecca Lambert, founder and CEO of…

Researchers at the University of California, Los Angeles (UCLA) Health Sciences have engineered a type of potent immune cell, called gamma delta T cell, that might be used as an “off-the-shelf” therapy for patients with ovarian and other difficult-to-treat cancers. Also known as allogeneic therapy, “off-the-shelf” therapy uses immune cells…

Researchers at the Hospital for Sick Children (SickKids), the Ontario Institute for Cancer Research (OICR), and the University Health Network (UHN) have developed a liquid biopsy that an initial study has shown provides earlier detection cancer in individuals with Li-Fraumeni syndrome (LFS) than existing methods. LFS is hereditary disorder that…

A simple model, developed by U.K. researchers using machine learning, can accurately predict lung cancer risk and identify people who need screening using just three variables— age, smoking duration, and pack–years. The University College London lung cancer death (UCL-D) and incidence (UCL-I) models performed as well as or better than…

The FDA has approved the first blood test that can help identify hundreds of potentially cancer-associated hereditary variants. The Invitae Common Hereditary Cancers Panel evaluates a blood sample to identify DNA variants in 47 genes associated with an elevated risk of developing certain types of cancer. The agency has granted de…

Research suggests that some women could forgo genetic counseling before or after taking a remote screening test for inherited breast or ovarian cancer risk without experiencing increased distress, anxiety, or depression. Furthermore, omitting counseling increases the number of people who complete screening, reports Elizabeth Swisher, a gynecologic oncologist at UW…

The American Association for Cancer Research (AACR) released its annual Cancer Progress Report on Wednesday that highlighted advances in cancer treatments and survival while also advocating for continued funding by the US government to sustain progress. “The advances in cancer research, particularly in the last two decades, have been breathtaking,”…

Moderna and Immatics are collaborating to “pioneer novel and transformative therapies for cancer patients with high unmet medical needs,” in a deal worth potentially $1.7B+. They will combine Immatics’ T cell receptor (TCR) platform with Moderna’s mRNA technology, and span modalities including bispecifics, cell therapy, and cancer vaccines.  Cambridge-based Moderna…