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Immune checkpoint inhibitors: Interaction between PD-1 (blue) on a T-cell and PD-L1  (red) on a cancer cell  blocked by therapeutic antibodies

USC Team IDs Biomarker for NSCLC Response to Chemoimmunotherapy

A team of researchers from USC Norris Comprehensive Cancer Center have identified a new biomarker that shows which patients with non-small cell lung cancer (NSCLC) will respond well to chemoimmunotherapy.
Cancer cell surrounded by therapeutic antibodies and cytokines among normal cells

Startup Siren Biotechnology Touts Its AAV-Cytokine Immunotherapy as Potentially Effective against All Cancers

Siren Biotechnology, which combines AAV gene therapy and cytokine immunotherapy into a single transformative modality emerged from stealth mode this week as ASGCT.
Glioblastoma, Brain metastasis,MRI Brain The doctor pointed out the location of the brain tumor on the computer screen.

Combination Oncolytic Virus and Immunotherapy Improved Overall Survival in Glioblastoma

The Phase I/II study, conducted by neurosurgeons at the University Health Network in Toronto, showed significant improvements in patient survival rates and tumor shrinkage.
Pancreatic cancer, illustration

Next-Generation Immunotherapy Stops Pancreatic Cancer Metastasis

Combining radiation with a novel immunotherapy drug was shown to stop metastasis in animal models of pancreatic ductal adenocarcinoma (PDAC), which accounts for 90% of pancreatic cancers.
Acute lymphoblastic leukemia ALL-L2 blood smear under light microscopy

Immunotherapy Substantially Improves Outcomes for Babies with Leukemia

Researchers led by a team from the Netherlands have shown that adding the immunotherapy blinatumomab to chemotherapy delays progression and improves survival for infants with an aggressive type of acute lymphoblastic leukemia.
Close up of melanoma

Melanoma Immunotherapy Shows Promising Results in Mice

Researchers from King’s College London and Guy’s and St. Thomas’ NHS Foundation Trust report that their newly developed class of immunotherapy has shown promising results against melanoma.
PD-1 Antibody Targeting Immune Checkpoint Inhibitor

Guardant and PICI Collaborate on Cancer Biomarker, Immunotherapy Response Study

Guardant Health and the Parker Institute for Cancer Immunotherapy (PICI) announced a collaboration on Tuesday to study the connection of cancer biomarkers and treatment response to immunotherapy spanning more than 14 different types of cancer.
Hospitalized cancer patient undergoing chemotherapy.

Lung Cancer Outcomes Improve when Immunotherapy is Given Before and After Surgery

Pre-surgical immunotherapy and chemotherapy followed by post-surgical immunotherapy significantly improved event-free survival (EFS) and pathologic complete response (pCR) rates compared to chemotherapy alone for patients with operable non-small cell lung cancer (NSCLC).
Melanoma cancer cells of human under microscope

Personalized mRNA Vaccine Boosts Immunotherapy for High-Risk Melanoma

Researchers have developed a personalized mRNA-based vaccine, mRNA-4157, that significantly delays disease recurrence in patients with resected high-risk melanoma when added to standard-of-care adjuvant pembrolizumab therapy.
PD-1 is a checkpoint to slow down T-cells. PD-1  (red) extends from the surface of a T-cell interacting with the ligand protein PD-L1 (yellow) from an antigen presenting cell.

Immunotherapy Response in Advanced Melanoma Affected by Prior Treatments

Responses to the immunotherapy PD-1 checkpoint blockade in patients with advanced melanoma was tied to whether they had received a previous immunotherapy, CTLA-4 blockade, as well as other factors.


Inside Precision Medicine