A small clinical trial conducted by investigators at Ludwig Cancer Research has shown that a treatment regimen for advanced ovarian cancer patients by combining adoptive T cell therapy (ACT) with a personalized cancer vaccine doubled overall survival time in patients. The research, detailed Thursday in Nature Cancer,  was led by…

A team of investigators at City of Hope, one of the largest cancer research and treatment organizations in the US, report in Nature Communications that they have engineered a CAR T cell therapy for advanced ovarian cancer that has shown promise in laboratory and preclinical models. Based on the preclinical…

A new study describes a new diagnostic approach that could help identify the 15% of women with ovarian cancer whose tumors are intrinsically refractory to standard platinum-based therapies, the most common type of chemotherapy for the disease. Most ovarian cancers are very sensitive to platinum therapy, at least initially. However,…

New findings from researchers at Nagoya University in Japan have revealed new potential biomarkers for ovarian cancer found in extracellular vesicles (EVs). The three previously unknown membrane proteins in extracellular vesicles (EVs) derived from high-grade serous ovarian carcinoma (HGSOC), a deadly subtype of epithelial ovarian cancer (EOC). The group used…

Researchers led by a team from the University of Helsinki in Finland have identified three different evolutionary states in tumors from patients with ovarian high-grade serous carcinoma (HGSC) that are characterized by distinct signaling pathways and associated with treatment response. HGSC is the most common epithelial ovarian cancer subtype and…

As part of the annual meeting of the American Association for Cancer Research (AACR) in Orlando, FL, researchers from the Perelman School of Medicine at the University of Pennsylvania have not only identified a new target for drug-resistant ovarian cancer but also provided supporting evidence for a potential treatment approach.…

Researchers have discovered a mechanism by which chemoresistant ovarian cancer cells signal neighboring cells to fall into a similar resistant state. A team from the University of Pittsburgh observed that so-called quiescent ovarian cancer cells, which are characterized by very slow growth, overexpress a normal ovarian protein called follistatin. That…

Data on over-the-counter (OTC) medicine purchases could spot ovarian cancer earlier, according to researchers in the U.K. The team hopes their findings will lead to an early alert system for this, and perhaps, other malignancies later. The Cancer Loyalty Card Study (CLOCS) looked at data from almost 300 women to…

Ioannis Zervantonakis, PhD, assistant professor of bioengineering at the University of Pittsburgh Swanson School of Engineering, and his team were awarded a four-year $792,000 grant by The American Cancer Society to understand the biology behind cell interactions that cause ovarian cancer to metastasize. To stop ovarian cancer from spreading throughout…

Women who are carriers of one of the BRCA1/2 cancer risk alleles are advised to have preventive surgery to stop ovarian cancer, but a new U.K. study reveals that extra surveillance can be effective in the short term for those who wish to delay surgery. The well-known BRCA1/2 gene variants…

A new variation of liquid biopsy technology claims to successfully boost ovarian cancer prediction in women with a cyst or other pelvic mass, according to a new study from the Wilmot Cancer Institute at the University of Rochester Medical Center published in Obstetrics & Gynecology “Green” journal. The approach improves the…

Scientists from the University of California (UC), San Diego, and their collaborators have demonstrated how key proteins act together to suppress antitumor activity in high-grade serous ovarian carcinoma (HGSOC) in a mouse model, revealing a new combinatorial strategy to treat this intractable malignancy. Hallmarks of a lethal form of ovarian…

Researchers at Helsinki University investigated how the genetic characteristics of ovarian cancer shape how tumor and immune cells communicate with each other and how BRCA1/2 mutations shape the cellular phenotypes and spatial interactions of the tumor microenvironment. “With the help of this revolutionary imaging technology and advanced data analysis, we…

Stem cell scientists have created fallopian tube-based organoids that may help predict which individuals with BRCA-1 mutations will develop ovarian cancer years or even decades in advance, and could be used to develop personalized therapies.   Their study was published this week in Cell Reports. Clive Svendsen, Ph.D., professor of…

UT Southwestern faculty say they have discovered what appears to be an Achilles’ heel in ovarian cancers, as well as new biomarkers that could point to which patients are the best candidates for possible new treatments. Their results suggest ribosome MARylation (the catalytic activity of mono-ADP-ribosyl-ates), promotes protein homeostasis in…