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Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Resistance in Neighboring Cells
Quiescent ovarian cancer cells, which are characterized by very slow growth, overexpress a normal ovarian protein called follistatin, which signals to local cancer cells to grow more slowly and evade killing by chemotherapy.
OTC Medicine Purchase Data Can Signal Ovarian Cancer
Data on over-the-counter (OTC) medicine purchases could spot ovarian cancer earlier, according to new research from a team in the U.K.
3D Models May Lead to Therapeutic Targets for Metastatic Ovarian Cancer
Researchers from the University of Pittsburgh Swanson School of Engineering were awarded a grant to determine the biology behind cell interactions that cause ovarian cancer to metastasize.
Extra Surveillance for Women at Risk of Ovarian Cancer Can Be Effective in Short...
Short-term surveillance can help improve outcomes and treatment costs before preventive surgery in women at high-risk for ovarian cancer.
RNA-based Algorithm Successfully Predicts Ovarian Cancers in Pelvic Mass
Known as MAGIC (Malignancy Assessment using Gene Identification in Captured Cells), the algorithm achieved a sensitivity for detecting epithelial ovarian cancer of 95% and an accuracy of 83% for detecting the disease.
Multifactorial Strategy Shows Promise For Lethal Ovarian Cancer
Scientists from the University of California (UC), San Diego, and their collaborators have demonstrated how key proteins act together to suppress antitumor activity in high-grade serous ovarian carcinoma (HGSOC) in a mouse model, revealing a new combinatorial strategy to treat this intractable malignancy.
Ovarian Cancer Genetics Shapes Tumor and Immune Cell Communication
Researchers have uncovered how tumor cells interact with the immune system in ovarian cancer. Utilizing highly multiplex immunofluorescence and image analysis, they investigated how the genetic characteristics of ovarian cancer shape how tumor and immune cells communicate with each other.
Researchers Create Organoids that Model BRCA-Positive Ovarian Cancer
The fallopian tube-based organoids may help predict which individuals with BRCA-1 mutations will develop ovarian cancer years or even decades in advance, and could be used to develop personalized therapies.
Ovarian Cancer “Achilles’ Heel” Revealed by UT Southwestern Researchers
This study identified mono (ADP-ribose) and NMNAT-2 as potential biomarkers for ovarian cancers, which may allow clinicians to determine which ovarian cancer patients may respond well and which will not and points to the therapeutic potential of developing an inhibitor for PARP-16.
Moffitt Researchers Find Clues Underlying Humoral Immunity in Ovarian Cancer
Researchers from the Moffitt Cancer Center have discovered potential reasons why humoral immunity, or antibody-based immunity, appears to be associated with better outcomes in some ovarian cancers, potentially opening a new line of therapeutic intervention.