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Published on September 7, 2022
Researchers at UT Southwestern Simmons Cancer Center report that lactate, a metabolic byproduct produced by cells during strenuous exercise, may rejuvenate immune cells that fight cancer. Their findings, published in Nature Communications, could eventually be used to develop new strategies to augment the anti-tumor effect of cancer immunotherapies. “The lactate that…
Published on March 15, 2024
With organ transplant rejection rates as high as 50% depending on the type of organ, there is a vital need for the development of more effective therapies to prevent the activation of the body’s immune response. Now, researchers at Houston Methodist Hospital say they have identified a subset of CD4+…
Published on February 28, 2024
New research shows that targeting the activin receptor 1C on T cells may boost immune system attack against cancer cells. As a potential new anticancer immunotherapy, it opens the door to new treatment protocols aimed at blocking its function. The team first found that the levels of protein activins, including…
Published on February 26, 2024
New research involving mice and with observations corroborated by fetal, neonatal, and adult human data from Cornell University demonstrates that a newborns’ T cells surpass those of adults at fighting off numerous infections. The new study clarifies why adults and infants respond differently to infection and may pave the way…
Published on January 31, 2024
Researchers in Japan and the United States have developed a new CRISPR-based technology that increases the recognition of cancer cells to the immune system. The findings, published in Proceedings of the National Academy of Sciences, were led by Koichi Kobayashi, professor at Hokkaido University and Texas A&M Health Center, and…
Published on November 9, 2023
A single, master genetic regulator can improve the effectiveness of T cells in cancer therapy and could extend their use for other diseases, researchers have discovered. A member of the BAF chromatin remodeling complex was able to reprogram T-cell genes to improve their cancer-killing abilities and reduce the chances of…
Published on May 24, 2023
Scientists at the German Cancer Research Center (DKFZ) sought to determine the role of gastrointestinal B cells in the development of nonalcoholic steatohepatitis (NASH), fibrosis, and NASH-induced HCC. They discovered B cells promote liver cancer with a dual strategy. Their findings are published in the Journal of Hepatology. “Worldwide, fatty…
Published on December 7, 2022
Cancer patients’ response to immunotherapy may be predictable in part based on their levels of CD8+ T-cell infiltration, according to a new study. Such drugs are one of the world’s highest selling classes, estimated to have netted over $31B in 2021 and expected to bring almost $150M by 2030. But…
Published on December 2, 2022
Buoyed by a recent proof-of-concept trial of its cytoxic T lymphocytes (CTL) targeting treatment of SARS-CoV-2 infection, late stage biopharma Tevogen Bio announced will begin work to study potential therapeutic use of its allogeneic genetically unmodified precision T cell technology in multiple sclerosis (MS) by developing Epstein-Barr virus (EBV) specific…
Published on April 14, 2022
A kind of kiss between cells, called trogocytosis, which can shut down anticancer activity plays a key role in the battle between the immune system and blood cancer cells, suggests early stage research from the University of Ottawa. “Trogocytosis modulates immune responses, with still unclear underlying molecular mechanisms,” the researchers…
Published on March 21, 2022
Research led by La Jolla Institute for Immunology in California has identified a genetic signature present in a type of immune cell known as a memory T cell that identifies patients with Parkinson’s disease, which the research team hopes could help find new treatment targets in the future. Around 680,000…
Published on March 9, 2022
A new mouse study by researchers at the Monash Biomedicine Discovery Institute (BDI), the Peter MacCallum Cancer Centre, and Cold Spring Harbor Laboratory demonstrates inhibiting the protein tyrosine phosphatase 1B (PTP1B) in T cells can help to suppress tumor growth. The findings are published in the journal Cancer Discovery in a paper…
Published on October 20, 2021
New research led by investigators at MIT, has demonstrated that a patient’s own live tumor cells, damaged by chemotherapy, may also augment antitumor immunity. The results suggest these live cell adjuvants may enhance the effectiveness of immune checkpoint blockade (ICB) in tumors that wouldn’t normally respond to such treatment alone.…
Published on September 17, 2021
New research from investigators at MIT may help guide vaccine developers to decide which proteins to include in new vaccines against cancer. Cancer cells display unique mutated proteins called neoantigens on their surfaces. Fragments of certain neoantigens when injected into the body can stimulate the body’s immune system to annihilate…
Published on July 22, 2021
Researchers at La Jolla Institute for Immunology (LJI) have discovered how to prevent T-cell exhaustion, which they hope will make CAR T-cell cancer therapies more effective. The newly reported findings demonstrate the key role of the transcription factor BATF in the cellular pathway that triggers T cell exhaustion, and show…