513 Results
Sort By:
Published on January 31, 2017
Researchers at the Oregon Health and Science University (OHSU) have uncovered a novel method for quickly and efficiently mapping the genome of single cells within the body—clearing the way for significant advances in precision medicine. The findings from this new study, which were published recently in Nature Methods through an…
Published on April 1, 2024
Biologists of all sorts seek the answer to this general question: What happens and where? The complexity of the answer and even the ability to address the question depends intimately on the problem being studied. A chain of technological advances over centuries, however, continues to give biologists tools to explore…
Published on June 28, 2023
A team of Austrian researchers using single-cell sequencing has uncovered how cancer cells prevent cells in their environment from fighting the tumor. The research, published in Nature Communications and led by Sabine Taschner-Mandl, PhD, head of the Tumor Biology Group at St. Anna Children’s Cancer Research Institute (St. Anna CCRI),…
Published on June 1, 2022
Originally Aired: June 24, 2022Time: 8:00 am PT, 11:00 am ET, 17:00 CET VIEW NOW The inherent complexity of cancer provides investigators and clinicians with a challenging mix of cells in various states to fully understand disease biology and inform therapeutic decisions. Empowering cancer researchers to explore fundamental biological questions that were…
Published on June 8, 2021
Renal cell carcinomas (RCCs) are heterogeneous cancers encompassing several histologically and molecularly diverse tumor groups. Thought to arise from kidney tubular epithelial cells, clear cell RCC (ccRCC) is the most common type. A new study using single cell RNA sequencing (scRNA-seq) revealed the cellular origins for more than 10 RCC…
Published on June 2, 2021
Austrian scientists have developed a quicker and less expensive method for RNA single-cell sequencing, which should help make large projects more feasible. RNA sequencing is being used more and more to assess how genes are expressed within cells as it gives researchers more information than simply looking at genomic data.…
Published on November 30, 2020
A pioneering method of uncovering gene function, called in vivo pertub-seq, has been used to study 35 de novo loss of function genes previously associated with autism spectrum disorder (ASD). Jin et al. used CRISPR-Cas9 to edit the genes and single-cell-sequencing (RNAseq) to study their function in developing mouse embryos.…
Published on June 29, 2020
Single cell sequencing has revealed the genetic diversity underlying the COLO829 melanoma cell line, which is a benchmark for evaluating somatic genetic alterations. A University of Southern California (USC) team performed a single experiment that determined shallow copy number profiling across many such cells can provide important biological insights, including…
Published on February 11, 2020
New advances in single cell RNA sequencing technology has brought researchers from the UK closer to discovering the cellular origin of a multitude of ovarian cancer subtypes, which they hope will eventually allow for the development a screening tool and better treatment options for this silent killer of women. Ovarian…
Published on May 22, 2018
Until recently, scientists studying multicellular organisms at the cellular level had one big problem: their techniques did not allow them to account for cell-to-cell variation. That’s because the technology required the use of bulk tissue samples and results could only be interpreted as an average of the cells in a…
Published on May 21, 2018
Drug discovery company Verge Genomics announced it will lead a consortium comprising the University of California, San Diego (UCSD) and VIB, the life sciences research institute, in Flanders, Belgium to sequence the genes expressed in the brains of patients with Parkinson’s disease at a single-cell resolution. According to Verge this…
Published on February 26, 2018
Scientists at the New York Genome Center (NYGC) and New York University (NYU) say they have begun to facilitate broad access to single-cell sequencing by developing a 3D-printed, portable, and low-cost microfluidic controller. To demonstrate the utility of the instrument in clinical environments, the researchers deployed the device to study…
Published on January 4, 2018
A new single-cell sequencing tool developed by researchers at the University of Texas MD Anderson Cancer Center has improved their understanding of how a common form of early-stage breast cancer advances to a more invasive form of the disease, and why some cancers go undetected. The researchers have developed topographic…
Published on May 8, 2024
Using large proteogenomic datasets, novel renal cell carcinoma (RCC) biomarkers were found in a new study led by University of Michigan Health Rogel Cancer Center researchers. The team carried out integrative analysis of datasets from both non-clear cell and clear cell RCC. Their findings should improve researchers’ ability to diagnose subtypes…
Published on April 9, 2024
A recent breakthrough by scientists at the St. Jude Children’s Research Hospital has shed light on which tumor cells in B-cell acute lymphoblastic leukemia (B-ALL) resist treatment and how this resistance can be overcome. The researchers, led by senior co-corresponding author Jun J. Yang, PhD, vice chair of the Department…