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Published on February 8, 2021
It’s been 20 years since the first human genome was sequenced and 10 years since the birth of psychiatric genomics. Like those who study chronic conditions such as cancer, researchers in the field of psychiatric genomics are dedicated to using genome-wide association studies (GWAS) to find candidate genes that, upon…
Published on January 26, 2021
A novel microneedle patch, developed by a team of engineers at the McKelvey School of Engineering at Washington University, St. Louis, when applied to the skin can both capture biomarkers and allow clinicians to detect the presence of the biomarker. The low-cost technology has the potential to eliminate the need…
Published on January 25, 2021
A highly detailed map of human skin cells—a component of the Human Cell Atlas research—reveals that cellular processes from skin cell development are re-activated in cells from patients with inflammatory skin disease. In addition, it uncovered that skin from eczema and psoriasis patients share many of the same molecular pathways…
Published on December 8, 2020
The CRISPR-Cas9 gene-edited therapy CTX001 has shown a consistent and sustained positive response in 10 patients treated for a pair of blood disorders—sickle-cell disease (SCD) and beta thalassemia—reported CRISPR Therapeutics and Vertex Pharmaceuticals the developers of the therapy. These are the first clinical studies of a CRISPR gene-editing candidate sponsored…
Published on October 6, 2020
The way cancer mutations accumulate in the genome depends on both the 3D structure of the chromosome and the factor that is causing the mutation, shows research from the University of Texas MD Anderson Cancer Center. The scientists believe this information could help to guide treatment better, as well as…
Published on September 28, 2020
Microbiomics is taking a sharp turn. Until now, the field was limited to fecal transplants from healthy patients to those with gut conditions. The transplant is an awkward procedure that also creates regulatory and other challenges. But as the field has progressed, companies today are pushing forward to adapt technologies…
Published on September 2, 2020
When a naturally occurring metabolite, alpha-ketoglutarate (AKG), was added to the regular diets of middle-aged mice, they remained healthier as they aged, and experienced a dramatically shorter time of disease and disability before they died, when compared with control animals. These are the findings of a double-blind study carried out…
Published on December 24, 2019
By Prabarna Ganguly, Ph.D. Over the last 20 years, three families have been unsuspectingly linked by an unknown illness. Researchers at the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, and other organizations have now identified the cause of the illness, a new disease called…
Published on May 23, 2019
Precision Medicine company Progenity, a developer of both diagnostic and therapeutic platforms, announced results from three studies that represent potential breakthrough methods for diagnosing, treating, and monitoring digestive diseases through ingestible technologies. The studies, which encompass both human and preclinical models, showed that the company’s ingestible diagnostic capsule provided autonomous…
Published on February 4, 2019
Traumatic brain injury (TBI) has recently become a serious societal concern, as the link between repetitive head traumas and neurodegenerative brain disease has come to light. Yet TBI is signficantly under-reported due to lack of adequate diagnostic tools, sparking great debate about this ‘silent epidemic,’ particularly among professional and youth…
Published on October 26, 2018
Investigators at the University of Colorado (CU) Anschutz Medical Campus have uncovered multiple genetic variants within a single gene that makes some people especially susceptible to middle ear infections. These findings could eventually lead to new ways of determining who is likely to get the infection and provide a path…
Published on June 11, 2018
Bentley University and Gravity Diagnostics said today they will partner on research intended to help doctors assess the likelihood of a patient becoming addicted to a prescription pain drug—and the likelihood of an already-addicted patient responding to a given treatment. Bentley University and Gravity Diagnostics said their three-year research partnership…
Published on May 16, 2018
Multifactorial diseases are notoriously difficult to treat, as their molecular roots are convoluted and enigmatic. Yet in the genomic age, new scientific endeavors are beginning to reveal some interesting connections between seemingly unrelated disorders. For instance, a new study from investigators at the University of California San Diego School of…
Published on August 23, 2016
NIH researchers have announced the discovery of a rare and sometimes deadly inflammatory disease, named Otulipenia, which affects primarily children and has a variety of symptoms including fever, skin rashes, diarrhea, joint pain, and overall failure of children to grow or thrive. The scientists also identified anti-inflammotory treatments for the…
Published on July 18, 2016
North Dakota-based Sanford Health, one of the country’s largest integrated health networks with 43 hospitals and nearly 250 clinics located in nine states, has tapped Translational Software Inc. (TSI) for its pharmacogenomics data and knowledge base, as it looks to significantly expand the system’s genomics program to multiple regions. TSI,…