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Published on May 9, 2024
Zenas BioPharma this week closed an upsized $200 million Series C financing. The company’s lead product candidate, obexelimab, is a bifunctional monoclonal antibody designed to bind both CD19 and FcγRIIb to inhibit the activity of B cells, plasmablasts, and CD19-expressing plasma cells to treat autoimmune diseases. The financing round was…
Published on May 6, 2024
Female mammals are more susceptible to autoimmune diseases because of how their X-chromosome is inactivated, new research from France suggests. Scientists “turned back on” the inactive X gene in a mouse model, which led to signs of autoimmune disease. It’s likely the findings will relate to people as well. The…
Published on February 28, 2024
A stunning response to CAR T therapy by patients with autoimmune disease was seen in a small study led by a group of German researchers. The use of CAR T in autoimmune diseases has been slowly ramping up over the last few years and this is one of the most…
Published on November 28, 2023
A team of international researchers, led by the University of Plymouth, has unveiled a novel technique that could pave the way for discovering and developing new therapeutics for prevalent autoimmune diseases. Reporting in Nature Biomedical Engineering, the researchers introduce the Secretion-Enabled Cell Ranking and Enrichment (SECRE) method, which promises to…
Published on September 13, 2023
Dark genome specialist ROME Therapeutics has completed an oversubscribed $72 million Series B extension financing, bringing the total Series B amount raised to $149 million. The dark genome includes long stretches of DNA that do not encode for traditional proteins. Boston-based ROME is developing therapies for a range of diseases,…
Published on September 12, 2023
Traditional vaccines work by teaching the immune system to recognize a virus or bacteria that needs to be attacked. Now, researchers at the University of Chicago’s Pritzker School of Molecular Engineering (PME) say they have developed a new vaccine that does just the opposite by removing the immune system’s memory…
Published on January 4, 2023
Gilead Sciences and EVOQ Therapeutics have announced a collaboration around EVOQ’s proprietary NanoDisc technology for the treatment of rheumatoid arthritis (RA) and lupus. NanoDisc is designed to enable lymph targeted delivery of disease-specific antigens for autoimmune diseases. The two companies will collaborate on preclinical development. EVOQ could receive up to…
Published on September 21, 2022
Researchers at Friedrich-Alexander-University Erlangen-Nürnberg (FAU), in Germany have successfully cured several patients suffering from severe systemic lupus erythematosus (SLE) using genetically modified immune cells known as CAR-T cells. CAR T cells are immune cells taken from an individual patient and genetically engineered to express proteins known as CAR—chimeric antigen receptors—on…
Published on September 20, 2022
Many previously unreported NFKB1 variants have been found in patients with immune system related illnesses in a study by researchers from the Institute of Biotechnology, University of Helsinki, and other international clinicians. The Helsinki researchers are pioneers in identifying mutations on the NFkB1-gene. The new report was featured in Frontiers…
Published on July 12, 2022
Scientists at Gladstone Institutes, UC San Francisco (UCSF), and Stanford School of Medicine report they have released the most detailed map to date of how complex networks of genes work together and the resultant effects these networks have on immune cell function and on the development of immune disease. The…
Published on May 25, 2022
An international team of researchers led by a physician from the Karl Landsteiner University for Health Sciences in Krems, Austria, has identified a duplication of the Interleukin 33 (IL-33) gene that causes a previously unidentified allergic and autoimmune disease. The diagnosis was provided to the 12-year-old boy who suffers from…
Published on April 11, 2022
Two research groups performed single-cell RNA sequencing (scRNA-seq) of immune cells and combined the data with fine mapping of autoimmune disease–associated genetic variants to provide a resource that allows the large-scale identification of genotype-phenotype interactions. The research, which is published in Science and brings together population genetics and scRNA-seq data,…
Published on July 28, 2020
A study carried out by scientists in the U.K. and Australia from the Cambridge Baker Systems Genomics Initiative shows that variants in some genes may predispose people to developing autoimmune diseases or allergies from an early age. Autoimmune diseases such as type 1 diabetes, rheumatoid arthritis and inflammatory bowel diseases…
Published on April 15, 2020
Scientists at the Wellcome Sanger Institute, Open Targets, Biogen, GSK, and their collaborators say they have found that T cells responded differently to immune signals the more “training” they had been exposed to, rather than being a simple switch from naïve to experienced. This could help guide research into finding…
Published on February 28, 2020
Researchers at the Ludwig-Maximilians-Universität (LMU) in Munich’s Christoph Klein Lab, have discovered the role of a membrane bound protein involved with the development of T Cells that may also play a role in the development of a group of rare diseases. Genetic mapping is a key component in understanding rare…