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Published on May 8, 2024
The FDA has approved Geneoscopy’s colorectal cancer screening test, which is the first such test based on RNA to be approved by the U.S. regulatory agency. In a Phase III trial published last year, the CRC-PREVENT trial, the noninvasive, multitarget stool RNA test called ColoSense was significantly more sensitive than…
Published on March 26, 2024
A single mutation in MUTYH, a gene known to cause colorectal cancer, may cause other solid tumors, according to a study of over 350,000 patient biopsy samples conducted by researchers at the Johns Hopkins Kimmel Cancer Center, the Johns Hopkins Bloomberg School of Public Health, and Foundation Medicine. Their findings…
Published on January 31, 2024
European cancer mortality predictions for 2024 highlight a concerning increase in colorectal cancer deaths among people aged 29–45 years that the researchers suggest is linked to increasing rates of overweight and obesity. For the 14th consecutive year, Carlo La Vecchia, professor of Medical Statistics and Epidemiology at the University of Milan…
Published on January 9, 2024
An experimental cancer vaccine developed by Elicio Therapeutics to target tumors with KRAS mutations has achieved good results in a Phase I trial in patients with residual pancreatic and colorectal cancer following earlier treatment. As reported in Nature Medicine, the majority of patients in the study (84%) had a T…
Published on December 27, 2023
Prior studies have linked high blood cholesterol levels to various cancers, including colorectal cancers. However, it hasn’t been clear that lowering cholesterol can prevent colorectal cancers. Now, researchers at Weill Cornell Medicine have found in mice hard-to-detect colorectal pre-cancerous lesions known as serrated polyps, and the aggressive tumors that develop…
Published on December 8, 2023
Researchers at Case Western Reserve University say that a class of diabetes drugs used to treat type 2 diabetes may reduce the risk of the development of colorectal cancer (CRC). The drugs, called glucagon-like peptide-1 receptor agonists, or GLP-1 RAs are medications that are given by injection to lower blood…
Published on November 22, 2023
Researchers from Aarhus University Hospital in Denmark have shown that the rate of colorectal cancer (CRC) recurrence has decreased to such a large degree since 2004 that changes in surveillance strategies may be warranted. The decreases were observed across all disease stages and, by 2019, recurrence rates were particularly low…
Published on August 23, 2023
Researchers at the Salk Institute and at the University of California, San Diego (UCSD), have discovered in a mouse model how altered bile acids resulting from high-fat diets (HFDs) increase the risk of colorectal cancer. The research, published in Cell Reports, showed that HFDs can change the microbiome and in…
Published on June 14, 2023
Researchers from the Institute for Molecular Medicine Finland (FIMM) have demonstrated that a colorectal cancer (CRC) polygenic risk score (PRS) they have developed has the potential to inform the timing of when patients should begin screening for the disease. Use of the PRS could help address the fact that despite…
Published on June 7, 2023
A blood test based on RNA and AI delivered 87% sensitivity and 95% specificity of detection across eight cancer types, according to results Exai Bio presented in a poster session at ASCO last weekend. This is an important new aspect to the highly competitive multi-cancer early detection (MCED) market. Most…
Published on June 6, 2023
A large-scale, longitudinal, study found that less than seven percent of cancer patients received germline genetic testing, even though it is recommended by practice guidelines to support targeted treatment and inform health decisions by relatives. The authors, who included researchers from Stanford and University of Michigan, noted that genetic testing…
Published on May 4, 2023
Four important signs and symptoms of early-onset colorectal cancer have been pinpointed in a study of insurance data by researchers at Washington University School of Medicine in St. Louis. They found that, between three months and two years before diagnosis, abdominal pain, rectal bleeding, diarrhea, and iron deficiency anemia each…
Published on January 11, 2023
Researchers in China have shown that using immune checkpoint inhibitors prior to surgery of patients with localized mismatch repair-deficient or microsatellite instability-high (dMMR/MSI-H) colorectal cancer (CRC) is an effective approach to treating the disease, as opposed to surgery followed by neoadjuvant therapy. The findings, published in JNCCN—Journal of the National…
Published on September 7, 2022
The convenience of pre-cooked and instant meals may make it easy to overlook their less-than-ideal nutritional value, but a team led by researchers at Tufts University and Harvard University hope that will change after recently discovering a link between the high consumption of ultra-processed foods and an increased risk of…
Published on August 15, 2022
The precision cancer therapy pralsetinib, designed to target cancers with fusion mutations in the RET gene, has achieved good results in a phase I/II trial led by researchers at the University of Texas MD Anderson Cancer Center targeting different solid tumors with these types of mutations. Published in the journal…