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3d illustration of a cross-section of a diseased skin with melanoma that enters the bloodstream and lymphatic tract

Immunotherapy Before Targeted Therapy Improves Survival in Advanced Melanoma

The DREAMseq trial appears to provide convincing data that treatment order—with immunotherapy first over targeted therapy—leads to survival benefits.
Immune checkpoint inhibitors: Interaction between PD-1 (blue) on a T-cell and PD-L1  (red) on a cancer cell  blocked by therapeutic antibodies

Melanoma ICI Therapy Response Predicted by New Biomarkers

New research leveraging machine learning has identified novel predictive biomarkers of response to immune checkpoint inhibitor (ICI) therapy for melanoma.
3d illustration of a cross-section of a diseased skin with melanoma that enters the bloodstream and lymphatic tract

‘Practice Changing’ Data Show Benefits of Cell Therapy in Advanced Melanoma

A team from the Netherlands Cancer Institute in Amsterdam have shown for the first time in a randomized, controlled trial that cell therapy can delay disease progression in patients with advanced melanoma when compared with standard immunotherapy.
3D structure of a melanoma cell derived by ion abrasion scanning electron microscopy.

Inhibiting a Metabolic Enzyme Stops Melanoma Tumor Growth

In a paper published in Nature Cell Biology, researchers at Sanford Burnham Prebys have shown for the first time that inhibiting a key metabolic enzyme selectively kills melanoma cells and stops tumor growth.
3d illustration of a cross-section of a diseased skin with melanoma that enters the bloodstream and lymphatic tract

How NRAS Mutation Leads to Melanoma

Using a preclinical model, researchers have described key features of a gene mutation responsible for 15% to 20% of all melanomas.
3d illustration of a cross-section of a diseased skin with melanoma that enters the bloodstream and lymphatic tract

Age-Related Factors Stimulate Dormant Melanoma Cells to Grow

Metastases from primary cancer tumors may remain dormant in distant tissues for many years or decades before they re-emerge and grow new tumors.
Melanoma cancer cells of human under microscope

Single-Cell Melanoma Maps Reveal Battle Between Tumor and Immune Cells

Cancer has been considered a disease of the genome. Recent studies, however, have begun to show the importance of the tumor's local microenvironment that nurtures and sustains these cells.
Melanoma cancer cells of human under microscope

Blood Test Can Detect Circulating Melanoma Cells in the Blood

Research from the University of Michigan shows that a microfluidic device can detect circulating melanoma cells in blood, which could be used to diagnose and monitor the treatment of melanoma patients following further validation.
3d illustration of a cancer cell in the process of mitosis

Melanoma Progression Revealed at Single-Cell Level by Spatial Maps

Researchers have created spatial maps of melanoma that show how individual cells interact as the cancer progresses. The maps reveal details of how melanoma suppresses the immune system as it takes over.
Melanoma cancer cells of human under microscope

New Advanced Melanoma Immunotherapy Regimen Approved by FDA

The FDA has approved the use of the anti-lymphocyte-activation gene (LAG)-3 agent relatlimab in combination with the anti-programmed death (PD)-1 drug nivolumab for patients with treatment-naïve advanced melanoma.

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