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Published on May 5, 2022
A protein called CDC7, which has been known to play an essential role early in the cell division process, can be switched to another protein called CDK1, a finding researchers at Weill Cornell Medicine and the Dana Farber Cancer Institute believe may lead to new cancer therapies. “The entry of…
Published on January 11, 2021
All cancer cells—rather than just a subset—can enter a sluggish, slow-dividing state if they come under threat. Then, after the threat has passed, they can wake up and begin replicating at full tilt. By entering and leaving a dormant state in such coordinated fashion, the cancer cells can defeat a…
Published on February 14, 2024
Researchers led by Didier Trono’s group at EPFL have uncovered a crucial survival tactic employed by cancer cells. The scientists identified a group of proteins, known as KRAB zinc finger proteins (KZFPs), that help cancer cells maintain genetic stability and avoid immune system detection. The team’s findings are published in…
Published on December 18, 2023
Immusoft has dosed the first patient with an engineered B cell therapy—ISP-001 for MPS I (Mucopolysaccharidosis type I). This approach has several potential advantages over current gene and cell therapies. It does not require preconditioning (myeloablative chemotherapy) or immunosuppression, is administered as an IV on an outpatient basis, and it…
Published on November 27, 2023
Using intestinal organoids, researchers at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) and the Institute for Basic Science have identified a novel gene, Daam1, as a key player in orchestrating the development of stem cells in the intestine. The human body, much like a well-maintained…
Published on November 9, 2023
Researchers from the Broad Institute of MIT and Harvard and Brigham and Women’s Hospital have made significant strides in understanding rheumatoid arthritis (RA) through new research that provides a cellular atlas of RA defining six subtypes of inflammation. The study, published in Nature, examined the cellular drivers of RA by…
Published on October 17, 2023
By William A. Haseltine Regenerative medicine has emerged as a promising treatment option for chronic medical conditions. Specifically, cell and gene therapies, innovative forms of regenerative medicine, have shown great potential in personalizing and targeting disease treatment. These cutting-edge therapies leverage a patient’s cells and genes to repair and regenerate…
Published on September 27, 2023
Scientists from IRB Barcelona’s Development and Growth Control Laboratory, led by ICREA researcher Marco Milán, PhD, have revealed how DNA damage caused by chromosomal instability increases the invasiveness of cancer cells. The findings were published this week in the journal Current Biology. Chromosomal instability (CIN) is a defining characteristic of…
Published on August 16, 2023
A team of investigators at City of Hope, one of the largest cancer research and treatment organizations in the US, report in Nature Communications that they have engineered a CAR T cell therapy for advanced ovarian cancer that has shown promise in laboratory and preclinical models. Based on the preclinical…
Published on July 19, 2023
The Merkel cell polyomavirus (MCV), usually harmless in most infected people, causes an aggressive skin cancer called Merkel cell carcinoma in about 3,000 people each year. New research published in PNAS from the University of Pittsburgh reveals the first steps explaining how the virus outpaces replication of its host cell,…
Published on May 25, 2023
Researchers from Fred Hutchinson Cancer Center, Scripps Research, and The International AIDS Vaccine Initiative (IAVI) report that the Phase I IAVA G001 clinical trial to test the safety and immune response of a self-assembling nanoparticle HIV vaccine has exhibited a strong T-cell response in human subjects. The data from the…
Published on May 10, 2023
Researchers at the University of Pittsburgh have developed a universal receptor system that allows T cells to recognize any cell surface target, providing the possibility for tailored CAR T cell and other immunotherapies used to treat diseases such as cancer. T cell therapies, especially those involving CAR T cells are…
Published on April 5, 2023
New findings from researchers at Linköping University in Sweden have shown that contrary to previous belief, stems cells remain in the bone marrow in acute lymphocytic leukemia. The disease, however, has been found to cause a hidden defect in the stem cells, that makes them lose their ability to form…
Published on March 8, 2023
Researchers have discovered a mechanism by which chemoresistant ovarian cancer cells signal neighboring cells to fall into a similar resistant state. A team from the University of Pittsburgh observed that so-called quiescent ovarian cancer cells, which are characterized by very slow growth, overexpress a normal ovarian protein called follistatin. That…
Published on February 22, 2023
The University of Texas MD Anderson Cancer Center and Replay have launched Syena, an oncology-focused company developing novel T cell receptor (TCR) natural killer (NK) cell therapies. The new company’s TCR NK cell platform is based upon the scientific discoveries of Katy Rezvani, MD, PhD, professor of Stem Cell Transplantation &…