87 Results
Sort By:
Published on April 11, 2024
Genetic testing could determine which young breast cancer survivors are at highest risk of a second primary breast cancer (SPBC) and thus help others avoid unnecessary treatment, according to a new study. Their findings suggests young breast cancer survivors without a germline pathogenic variant have a low risk of developing…
Published on February 26, 2024
A new process tested at University of Kentucky (UK) expands access to germline genetic testing for cancer patients by reporting research-grade germline sequencing to the clinical oncology team. Over a third of pathogenic/likely pathogenic germline variants (PGVs) identified using a universal testing strategy would have been missed by a guideline-based…
Published on August 15, 2023
Medical genetics company Invitae announced that data from its PROCLAIM clinical trial shows the benefit of pathogenic germline variant (PGV) testing for all prostate cancer patients. According to the data, nearly half of all prostate cancer patients with clinically actionable inherited PGVs could be missing out on vital, targeted care…
Published on June 6, 2023
A large-scale, longitudinal, study found that less than seven percent of cancer patients received germline genetic testing, even though it is recommended by practice guidelines to support targeted treatment and inform health decisions by relatives. The authors, who included researchers from Stanford and University of Michigan, noted that genetic testing…
Published on April 10, 2024
Encouraging results from this trial were presented at the American Association for Cancer Research (AACR) Annual Meeting 2024 by Timothy Yap, MBBS, PhD, of the University of Texas MD Anderson Cancer Center. Specifically, Yap reported that saruparib demonstrated early efficacy and a favorable safety profile in patients with HRR-deficient breast…
Published on November 16, 2023
A new qualitative study of how to properly prepare cancer patients for unanticipated inheritable genetic findings found their emotions ranged from gratitude to regret based on how much genetic counseling they received prior to tumor sequencing. These findings from research conducted by City of Hope with support from the American…
Published on October 25, 2023
Researchers at the Hospital for Sick Children (SickKids), the Ontario Institute for Cancer Research (OICR), and the University Health Network (UHN) have developed a liquid biopsy that an initial study has shown provides earlier detection cancer in individuals with Li-Fraumeni syndrome (LFS) than existing methods. LFS is hereditary disorder that…
Published on October 2, 2023
The FDA has approved the first blood test that can help identify hundreds of potentially cancer-associated hereditary variants. The Invitae Common Hereditary Cancers Panel evaluates a blood sample to identify DNA variants in 47 genes associated with an elevated risk of developing certain types of cancer. The agency has granted de…
Published on April 12, 2023
As he devises a tiny plasmonic nanopore system to capture even rare antigens and their ligands from tumors, George Alexandrakis is toiling at the vanguard of cancer research. The University of Texas at Arlington bioengineering professor is developing a way of using even very small samples of tissue or blood…
Published on March 13, 2023
New research published today in JNCCN‑Journal of the National Comprehensive Care Network adds more evidence to how the lack of genomic research for people of African Ancestry continues to negatively affect efforts to reduce disparities in cancer care for this group of patients. The researchers note that this is especially…
Published on February 27, 2023
A research team led by the University of Portsmouth in the U.K. has discovered that the Duchenne muscular dystrophy gene DMD is expressed differently in a range of different cancers in addition to causing the inherited degenerative muscle disease. As reported in the journal Cancers, they found that many cancerous…
Published on February 16, 2023
New evidence shows that germline-somatic associations can affect cancer development. In a large-scale analysis of data from the Dana-Farber Cancer Institute across 11 cancer types, researchers found that certain variants were associated with a decreased risk of somatic mutations, while others were linked to a higher risk. This study appeared…
Published on January 20, 2023
A massive, multinational genomic study has uncovered several genetic mutations that operate through specific biological pathways to increase susceptibility to sarcoma cancers. The genetic variants increased the risk of inherited sarcomas by altering telomere biology and mitotic function, both of which are fundamental to chromosome integrity. The findings, outlined in…
Published on January 4, 2023
The molecular function of 87 inherited genetic variants affecting the risk of prostate cancer have been identified in a new study using three-dimensional mapping, and the majority appear to control the activity of genes located far away from the risk variants themselves. The study, which was published in Cancer Discovery, also…
Published on November 9, 2022
Many studies have been conducted over the past 15 years of the genetic factors for breast cancer risk. Led by researchers at Vanderbilt University, the largest genetic study in breast cancer risk included data from more than 386,000 women from Asian and European ancestry to provide the latest understanding of…