1018 Results
Sort By:
Published on May 1, 2024
Researchers at the University of Florida report they have developed an mRNA cancer vaccine that quickly reprograms the immune system to attack glioblastoma in a first-ever human clinical trial of four adult patients. Their results published in Cell mirror those from preclinical mouse studies, and from a newly reported trial…
Published on April 29, 2024
The Human Immunome Project, a global nonprofit scientific initiative, has released its plans to decode and model the human immune system by generating the world’s most diverse and largest immunological dataset to date. Understanding the complexities of the human immune system is essential for developing treatments against different diseases—including cancer,…
Published on April 24, 2024
Scientists have discovered that removing Jagged2, a molecule involved in the Notch signaling pathway that regulates tumor cell growth, stimulates the spread of macrophages to recognize and eliminate non-small cell lung cancer (NSCLC) cells. The Notch family of receptors are bound by a group of ligands, including Jagged 1 and…
Published on February 14, 2024
Researchers led by Didier Trono’s group at EPFL have uncovered a crucial survival tactic employed by cancer cells. The scientists identified a group of proteins, known as KRAB zinc finger proteins (KZFPs), that help cancer cells maintain genetic stability and avoid immune system detection. The team’s findings are published in…
Published on January 31, 2024
Researchers in Japan and the United States have developed a new CRISPR-based technology that increases the recognition of cancer cells to the immune system. The findings, published in Proceedings of the National Academy of Sciences, were led by Koichi Kobayashi, professor at Hokkaido University and Texas A&M Health Center, and…
Published on January 31, 2024
New findings from the National Institutes of Health (NIH) researchers showed that people who switched to a vegan or ketogenic diet showed rapid and distinct changes in their immune system. The small study, reported in the journal Nature Medicine, closely monitored the biological responses of people who sequentially ate vegan…
Published on October 11, 2023
Researchers at the University of Texas at Austin (UT) have developed a drug able to restore the effectiveness of immune cells fighting cancer, slowing tumor growth, and increasing lifespan in mouse models of melanoma, bladder cancer, leukemia, and colon cancer. One of the most prevalent genetic abnormalities observed in multiple…
Published on July 21, 2023
A U.K. and Swiss study suggests that our immune system does not simply shape our microbiome, but that our microbiome also shapes our immune system. The research in fruit flies, published in Science, supports the idea that specific host immune genes have been tailored or selected for to deal with…
Published on June 23, 2023
Research lead by the St. Anna Children’s Cancer Research Institute (St. Anna CCRI) in Austria, has revealed a previously unknown genetic disease, connecting disruptions of blood formation to defects in the immune system and inflammatory processes. Four unrelated children present to the hospital with similar symptoms—severe inflammation affecting various organs…
Published on May 2, 2022
A new study in mice, zebrafish, and human cells, led by the University of Copenhagen, shows how the sleep-related protein hypocretin is regulated in cells by microRNA. Hypocretin is a protein suspected to play a role in both insomnia, which is a decreased ability to fall asleep at night, and…
Published on February 16, 2022
Ovarian cancer is the most lethal gynecologic malignancy and, despite their promise, immunotherapies have only modest efficacy against it. Now researchers at the University of Helsinki have uncovered new evidence about how tumor cells interact with the immune system in this particularly aggressive type of cancer, which affects about 240,000…
Published on December 7, 2021
Changes in the immune system after pregnancy could help women to fight off breast cancer, suggest findings of an animal study led by Cold Spring Harbor Laboratory scientists. Using a mouse model, the research team found that a type of immune cell called gamma delta natural killer T-like cells (NKTs)…
Published on December 3, 2021
Researchers at the University of Pittsburgh School of Medicine report in the journal Immunity, that a bacterium common in the mouse gut microbiome may aid the immune system in fighting cancer cells in the colon. These new findings could eventually inform the development of new therapeutics based on the small…
Published on June 3, 2021
Researchers at the Francis Crick Institute have uncovered a protein that aids tumors to evade the immune system and is a likely candidate as a new immunotherapy target. Their findings are published in the journal Cell in a paper titled, “Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity.” “Cross-presentation of antigens from…
Published on February 4, 2021
Research from the University of Pittsburgh School of Medicine suggests that selective deletion mutations drives evolution of the SARS-CoV-2 virus to avoid being targeted and destroyed by neutralizing antibodies from the immune system. Mutation rate in coronaviruses is actually lower than other viruses such as the flu and HIV because…