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Glioma - brain tumor

New Drug Class Shows Efficacy in Drug-Resistant Glioblastoma

A new class of glioma and glioblastoma (GBM) drugs exploit tumors that lack the DNA repair enzyme O6-methylguanine methyl transferase, or MGMT.
Glioblastoma brain cancer, CT scan

Gallium-Based Treatment for Glioblastoma Advances to Clinic

An innovative oral treatment for glioblastoma, which manipulates the way cancer cells metabolize iron, has entered phase I clinical trials.
Glioblastoma brain cancer, CT scan

Combination Therapy against Glioblastoma Shows Promise in Animal Models

A novel combination therapy involving short bursts of radiation therapy and natural nanoparticle-based immunity has been developed by researchers at Massachusetts General Hospital (MGH).
Glioblastoma brain cancer, CT scan

Protein Found That Could Help Prevent Glioblastoma Recurrence

Enhancing the activity of a protein that is not active enough in glioblastoma cells could help improve treatments and prevent recurrence in patients with this aggressive cancer by ensuring tumor cells die and are not allowed to recover.
Glioblastoma brain cancer, CT scan

Study Links Glioblastoma Tumors to Personalized Treatments

New research on patients with glioblastoma multiforme (GBM) has identified potential new targets for individualized treatments of the disease as well as a way to link patients to these treatments.
Glioblastoma brain cancer, CT scan

Genetic Finding Reveals Potential New Glioblastoma Treatment

Research findings provide evidence that targeting the galectin1 protein, in combination with radiation therapy, can pave the way for future clinical trials to treat glioblastoma tumors.
Glioma - brain tumor

Engineered Natural Killer Cells Help Overcome Immune Suppression in Glioblastoma

The researcher's findings suggest that engineering NK cells to resist immune suppression may be a feasible path toward using NK cell-based immunotherapies for treating glioblastoma.
Glioblastoma brain cancer, CT scan

Targeting Specific Enzyme May Improve Glioblastoma Therapy

After analyzing 330 metabolism genes in a pre-clinical model of glioblastoma, MD Anderson researchers discovered that several enzymes involved in fatty acid metabolism were important for glioblastoma cells.
Glioma - brain tumor

New CAR T Method Clears Glioblastoma Tumors in Preclinical Study

While current CAR T cell approaches to cancer treatment have focused on repurposing existing antibodies, Australian researchers have instead harnessed a patient's own white blood cells to recognized and destroy their own cancer.
Glioblastoma brain cancer, CT scan

Mechanism of Drug Resistance in Glioblastoma Identified

To study the effects of SCD inhibition, the team treated glioma-bearing mice with temozolomide (TMZ) — a currently used agent against glioblastoma — against SCD inhibition with the agent CAY10566 and TMZ.